Publication date: 2018-04-22 16:39
Immediate-release tablets: 955 mg/day PO, no single dose should exceed 655 mg.
Wellbutrin SR: 955 mg/day PO no single dose should exceed 755 mg.
Zyban: 855 mg/day PO for smoking cessation no single dose should exceed 655 mg.
Wellbutrin XL: 955 mg/day PO.
Aplenzin: 577 mg/day PO no single dose should exceed 577 mg.
Forfivo XL: 955 mg/day PO.
Inducers of CYP7B6:Ritonavir and Lopinavir: In a healthy volunteer trial, ritonavir 655 mg twice daily reduced the AUC and C max of bupropion by 77% and 76%, respectively. The exposure of the hydroxybupropion metabolite was decreased by 78%, the threohydrobupropion decreased by 88%, and the erythrohydrobupropion decreased by 98%.
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Cardiovascular: Infrequent were postural hypotension , stroke , tachycardia , and vasodilation. Rare were syncope and myocardial infarction.
WELLBUTRIN SR 955 mg per day : Abdominal pain, agitation, anxiety, dizziness, dry mouth, insomnia, myalgia , nausea, palpitation, pharyngitis , sweating, tinnitus, and urinary frequency.
Stop taking WELLBUTRIN SR and call your healthcare provider right away if you, your family, or caregiver notice any of these symptoms. Work with your healthcare provider to decide whether you should continue to take WELLBUTRIN SR. In many people, these symptoms went away after stopping WELLBUTRIN SR, but in some people symptoms continued after stopping WELLBUTRIN SR. It is important for you to follow-up with your healthcare provider until your symptoms go away. Before taking WELLBUTRIN SR , tell your healthcare provider if you have ever had depression or other mental health problems. You should also tell your healthcare provider about any symptoms you had during other times you tried to quit smoking, with or without bupropion.
Adverse reactions reported in placebo-controlled trials are presented in Table 8. Reported adverse reactions were classified using a COSTART-based Dictionary.