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Naloxone: Uses, Dose & Side Effects

Publication date: 2018-04-22 20:39

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According to Glick, Howard Lotsof "thought if he told the world about [ibogaine] they would embrace him as a savior and he would rid the world of this terrible scourge of addiction."

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There was a scientific method to this madness. The experiment was the work of Dr. Stanley Glick, former head of the Department of Neuropharmacology and Neuroscience at Albany Medical College. An addiction researcher (who also happens to moonlight as a jazz trumpet player), Glick chose &ldquo Four&rdquo as a way to mimic the sort of stimuli that can induce relapse in drug-addicted humans.

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Although the vaccine is technically competing with 68-MC, Glick says he hopes the rival treatment turns out to be safe and effective. His concern, however, is that even if the improved vaccine totally blocks the effects of cocaine, addicts will end up substituting other stimulants, such as meth, to achieve a similar high.

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A few years prior to the NIDA vote, Glick began collaborating with a chemist at the University of Vermont named Martin Kuehne. Kuehne had experience synthesizing medications for cancer and other diseases, and together they had the idea of tweaking the basic chemical structure of ibogaine to eliminate the side effects while keeping the potent anti-addiction properties. After testing about 65 different compounds all close chemical cousins of ibogaine Glick settled on 68-MC.

As an analogy, suppose you were to tell an exterminator that you have a termite infestation in your home. The exterminator is a professional whose advice you trust. Image he tells you that the best course of action would be to use a chemical which is known to eat away at both the wood and foundation of homes, as well as cause irreparable damage to furniture and windows. Would you still go ahead with it?

So one idea is that long-term stimulation from the ingredient in marijuana that produces a high tetrahydrocannabinol (THC) alters the body s pain system in a way that results in the symptoms of cannabinoid hyperemesis syndrome.

Glick figured a few preliminary tests on rats would debunk Lotsof&rsquo s wild claims, but he became intrigued when animals trained to self-administer morphine stopped taking the drug for days and even weeks after being dosed. He set out to find the precise &ldquo mechanism of action&rdquo in the brain that caused the phenomenon. A few years later, Glick ended up with 68-MC.

After injecting naloxone, stay with the person and watch for continued signs of overdose. You may need to give another injection every 7 to 8 minutes until emergency help arrives. Follow all medication instructions carefully.

If you have any questions, you could call your doctor, but if you are in doubt whether someone needs immediate medical attention, you should go directly to a hospital emergency department.

This was no ordinary vaccine. Researchers from Baylor University had modified the common medicine to fight cocaine. If it worked the way it was intended, the vaccine would make it nearly impossible for people to feel the effects of snorting, smoking, or injecting cocaine. The hope was that the test subjects would lose their taste for the drug when they found out it no longer delivered the high they craved.

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Naloxone: Uses, Dose & Side Effects Antidote for nausea caused by alendronate

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