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Publication date: 2018-05-26 04:39

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Does it make any difference which of the four drugs for erectile dysfunction you take? "Yes, there can be differences," says Dr. Louis Liou, chief of urology at Harvard-affiliated Cambridge Health Alliance in Boston. "For new patients, I have them try different ones to see what works best."

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Given the success of drugs to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra), drug companies have sought a comparable drug for women.

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I know it gives you an erection but ­ how does it do that? And why does Viagra only work when the man is sexually stimulated?

These meds only work when sexually aroused because the brain really is the master sex organ. Only when visual, tactile, or other stimuli cause the thought of sex are hormones released from the brain to begin the cascade of events that result in an erection. Sometimes something blocks a step toward that end. Viagra removes the block so things can proceed normally. Until the process begins, there is nothing for Viagra to do.

Men who suffer from erectile dysfunction often produce too little amounts of NO. This means that the small amount of cGMP they produce is broken down at the same rate and therefore doesn t have the time to accumulate and cause a prolonged vasodilation effect.
Sildenafil (Viagra) works by inhibiting the enzyme PDE5. This means that cGMP is not hydrolysed as fast and this allows the smooth muscle to relax.

One ED drug, Cialis, is FDA-approved for use daily in a dose of or 5 milligrams. This helps to produce erections on demand and may also help relieve urinary problems, like difficulty starting urination, that result from an enlarged prostate.

The study involved a group of 88 consecutively studied patients with clinical and radiological evidence of idiopathic NPH, for whom a frontal brain biopsy was obtained. For 79 patients, hydrodynamic criteria of NPH were fulfilled and a ventriculoperitoneal shunt was performed. The dosimetry was characterized by two independent methods: thermoluminescent dosimeters and radiochromic film.

Diabetes is a condition where there is too much sugar, or glucose, in the blood. Over time, high blood sugar levels can damage nerves and blood vessels—like the ones that produce erections. When this occurs, diabetes can lead to ED.

Furthermore, possible correlations between white matter lesion scores, ventricular width, and age were investigated. Normal-pressure hydrocephalus (NPH) is a potentially treatable syndrome with abnormal cerebrospinal fluid dynamics. Meningeal fibrosis and/or obliteration of the subarachnoid space has been suggested as the pathoanatomic basis. The purpose of the present study was to investigate whether meningeal fibrosis causes increased resistance to cerebrospinal fluid outflow (R(out)) and/or increased B-wave activity and whether pathological changes in the brain parenchyma after brain compliance, causing increased B-wave activity.

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